It happened on the A141 near Wimblington on Friday (24th June).
At about 4.15am a Citroen Relay van was involved in a collision with a HGV.
Officers, paramedics and fire crews all attended the scene.
A man, believed to be in his 30s, who was driving the van died at the scene. Another man who was driving the HGV was taken to hospital for treatment. His injuries are not thought to be life threatening.
The road is closed between Wimblington and the Slade End roundabout near Chatteris.
Anyone who witnessed the collision is asking to call police on 101 or visit www.cambs.police.uk/report quoting incident 61 of 24 June.
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